5 best abstracts
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Update on AL Base: a unique platform tool to study amyloidogenic immunoglobulin light chain sequences
Prokaeva T, Spencer B, Chan GG, Bhutkar A, Klimtchuk ES, Connors LH, Seldin DC, Sanchorawala V, and Skinner M
Amyloidosis Center, Boston University School of Medicine, Boston, MA, USA -
Polymorphic hierarchy and zipper-like packing of light chain-derived amyloid-like fibrils
Andreas Schmidta, Karthikeyan Annamalaia, Matthias Schmidta, Nikolaus Grigorieffb, and Marcus Fändrich Institute for Pharmaceutical Biotechnology, Ulm University, 89081 Ulm, Germany. Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn VA 20147, USA
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Whether endoproteolysis releases an amyloidogenic variable domain from an antibody light chain dimer depends on its kinetic stability
Gareth J Morgan and Jeffery W Kelly, The Scripps Research Institute, La Jolla, California, USA
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Characterization of a novel bifunctional “peptope” for pre-targeting immunotherapy of visceral amyloidosis
Wall, J. S.a,b, Williams, A.a, Martin, E. B a, Richey,T.a, Stuckey, A.a, Macy, S.a, and Kennel, S. J.a,b
Departments of aMedicine and bRadiology, University of Tennessee Graduate School of Medicine, Knoxville, TN, USA -
Systebryl (PTI-110) is a novel small molecule that modulates aggregation of patient derived amyloid and recombinant immunoglobulin light chain: a potential AL amyloidosis therapeutic
Esposito, Luke1; Cummings, Joel1; Chong, Tiana1; Klimtchuk, Elena2; Connors, Lawreen2; Seldin, David2; Duchin, Ken1.1ProtaMed, Inc., Kirkland, WA, USA; 2Amyloidosis Center, Boston University, Boston, MA, USA